The reference site for Nicardipine

Nicardipine hydrochloride (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the dihydropyridine class of calcium channel blockers.

WHAT IS Nicardipine?

Nicardipine is in a class of drugs called calcium channel blockers. This medicine relaxes (widens) your blood vessels, which makes it easier for the heart to pump and reduces its workload.

This medicine is used to treat hypertension (high blood pressure) and angina (chest pain).

 

Brand Name(s): Cardene; Cardene SR
CAS nº: 55985-32-5
(nye KAR de peen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to nicardipine and its correct use. Please read them carefully.

FDA Information

Nicardipine was approved by the FDA in December 1988. However, the patent for both Cardene® and Cardene SR® expired in October 1995.

A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Nicardipine dilates arteries in the body and is useful in the treatment of high blood pressure.

It also lowers the pressure burden on the heart, and is useful alone or in combination with beta-blockers in the treatment of angina related to exertion.

Drug Class And Mechanism: 

Nicardipine belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates these arteries. Relaxing the artery muscles lowers blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing the heart burden lessens the heart muscle’s demand for oxygen, and helps prevent angina in patients with coronary artery disease.

Unlike other calcium blockers, nicardipine has little effect on the heart muscle or on the electrical conduction of the heart.

Other uses for this medicine

Nicardipine is also used sometimes to treat congestive heart failure.

Nevertheless, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Nicardipine comes as a regular capsule and as an extended-release (long-acting) capsule, to be taken orally. The regular capsule is usually taken three times a day. The extended-release capsule is usually taken two times a day.

Take this medicine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Do not crush, break, or chew the extended-release (SR) capsules. Swallow them whole. They are specially formulated to release the medication slowly in the body.

Do not stop taking this medicine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse.

Grapefruit and grapefruit juice may interact with nicardipine. The interaction could have potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Furthermore, do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What special precautions should I follow?

BEFORE TAKING NICARDIPINE:

Tell your doctor if you have kidney disease, liver disease, another disease of the heart or blood vessels such as sick sinus syndrome, aortic stenosis, heart failure, low blood pressure, or coronary artery disease. You may not be able to take nicardipine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Moreover, please inform your doctor if you are taking any of the following drugs: another heart medication to treat the same or another condition, cimetidine (Tagamet®, Tagamet HB®), or cyclosporine (Sandimmune®, Neoral®). You may not be able to take nicardipine, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with nicardipine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Nicardipine is in the FDA pregnancy category C. This means that it is not known whether this medicine will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Furthermore, nicardipine passes into breast milk and may affect a nursing infant. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

If you are over 65 years of age, you may be more likely to experience side effects from nicardipine. Your doctor may prescribe a lower dose of this medication.

Please note that grapefruit and grapefruit juice may interact with nicardipine. The interaction could have potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Follow any recommendations your doctor makes about diet or exercise.

Use this medication with care when you stand or sit up from a lying position, especially if you wake up during the night. You may become dizzy when changing positions.

Use alcohol cautiously. Alcohol may further lower blood pressure and increase drowsiness or dizziness while taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose.

It is strongly advised never to take a double dose of this medication.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking nicardipine and contact your doctor immediately or seek emergency medical treatment:

an allergic reaction (such as difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives)
unusually fast or slow heartbeats
fainting or severe dizziness
abnormal behavior or psychosis
chest pain or worsening angina
jaundice (yellowing of the skin or eyes)
swelling of the legs or ankles

Other, less serious side effects may be more likely to occur. Continue to take nicardipine and talk to your doctor if you experience

unusual headache, fatigue, or tiredness
dizziness
flushing
rash
insomnia
vivid or abnormal dreams
increased urination
dry mouth
nausea or constipation
nervousness or tremor

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Try to keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed, and talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services on 911.

Symptoms of overdose may include:

dizziness
weakness
chest pain
shortness of breath
fainting
an unusually fast or slow heartbeat
coma
slurred speech
confusion

Product Images

PICTURES OF NICARDIPINE PILLS

Below you will find images and specific information on the principal types of nicardipine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

 

Name: NICARDIPINE
Strength(s): 20 MG
Imprint: ZENITH 20 mg 4288
Manufacturer: IVAX PHARMACEUTICALS

Name: NICARDIPINE
Strength(s): 20 MG
Imprint: MYLAN 1020
Manufacturer: MYLAN

Name: NICARDIPINE
Strength(s): 20 MG
Imprint: G 0041
Manufacturer: PAR PHARM.

Name: NICARDIPINE
Strength(s): 20 MG
Imprint: 93 793
Manufacturer: TEVA USA

Name: CARDENE®
Strength(s): 30 MG
Imprint: CARDENE ROCHE 30 mg
Manufacturer: ROCHE LABS.

Name: NICARDIPINE
Strength(s): 30 MG
Imprint: Zenith 30 mg 4289
Manufacturer: IVAX PHARMACEUTICALS

Name: NICARDIPINE
Strength(s): 30 MG
Imprint: MYLAN 1430
Manufacturer: MYLAN

Name: NICARDIPINE
Strength(s): 30 MG
Imprint: 93 794
Manufacturer: TEVA USA

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